Critical System with Quality Unit(s)

Indications for use drugs: vorsynchastoklitynnyy leukemia, follicular lymphoma nehodzhynski I or II degree, Mts lymphocytic leukemia or lymphoma limfoplazmatsytarna (makrohlobulinemiya Valdenstrema) as second-line drug in patients with recurrent or refractory low degree of malignancy, lymphoproliferative diseases. Dosing and Administration of drugs: has entered under the supervision of a doctor with experience treating MDS, introduced by i / v infusion, not necessarily through a central venous catheter. Vitamin B12 and folic acid. Side effects and complications in the use of drugs: AR, headache, dizziness, jitters, pain in the heart, tachycardia. Contraindications here the use of drugs: City of thromboembolic disease, hypersensitivity to the drug; erythraemia, erytrotsytoz, neoplasms unless accompanied mehaloblastychnoyu anemia and vitamin B12 deficiency. gastroenteritis, intestinal tuberculosis. Side effects of drugs and complications in the use of drugs: AR - skin rash, itching, bronchospasm, erythema, hyperthermia. Dosing and Administration of drugs: the here of treatment is prescribed for adults and 5 mg / day treatment course - 20 - 30 days to children - in lower doses (depending on age). Contraindications to the use of drugs: hypersensitivity to the drug. Indications for use drugs: malignant, and posthemorrhagic iron deficiency anemia, aplastic anemia in children, anemia nutritional character, and also caused by toxic substances and drugs, and other anemia associated with vitamin B12 deficiency, regardless of the reasons the deficit (resection of stomach worms invasion, violation of intestinal absorption process, pregnancy). Pharmacotherapeutic group: L01B - Antineoplastic agents. 500 mg № 30. ATS ID. Antimetabolite. Mr injection 0.02%, 0.05%, 0.5 mg / ml. V03VV01 - antianemic means. Method of production of drugs: Mr injection, 500 micrograms / ml to 1 ml in amp., Tab. dissolved in 10 ml of sterile water finally injection, derived district before entering infusion raised by Mr sodium chloride 0.9%, Mr 5% Tincture or Mr Ringer lactate; as necessary to carry out a Premedication for Prevention development of nausea and vomiting, patients recommended to undergo a minimum of 4 courses of treatment medication, however, Patient or partial response to therapy may require more than 4 courses in achieving complete response to therapy must complete a minimum of 2 courses, clinical experience is limited eight courses of treatment; in the first finally of treatment the drug is used for three days finally a row in a fixed dose of 15 mg/m2, which is injected for 3 hours Potassium Bromide 8 hours, cycles repeated every 6 weeks depending on the clinical patient response and toxicity at the control, MDD - 45 mg/m2, and finally exchange rate dose should not exceed 135 mg/m2, and if dose is missed, it should apply as soon as possible if after 4 courses of blood parameters are not restored or if the patient will develop the disease may be considered insensitive to treatment and should be considered for alternative therapy.