gout attack through the mobilization of uric acid in gouty nodules and other depot, nausea, vomiting, diarrhea, reversible increase of transaminases and alkaline phosphatase in the blood, hepatitis, stomatitis, G cholangitis, leukopenia, leukocytosis, eosinophilia, severe bone marrow damage (thrombocytopenia, agranulocytosis, aplastic anemia), especially in patients with renal failure, bradycardia, hypertension, dizziness, headache, drowsiness, weakness, fatigue, ataxia, depression, convulsions, paresis, paresthesia, sachem peripheral neuritis, myalgia; senses: blurred vision, cataract, breach of taste; interstitial nephritis with lymphocytic infiltration, uremia, hematuria, ksantohenni stones, AR Full Weight Bearing erythema, hives, itching, fever, chills, arthralgia, exudative erythema multiforme, Lyell-m s, alopecia, impotence, gynecomastia, diabetes, in patients with renal sachem if the dose is lowered, sachem develop vasculitis with skin changes, then the process may spread to the kidneys and liver and if you have vasculitis application drug be stopped immediately. The main pharmaco-therapeutic effects: a significant analgesic and anti-inflammatory action, has a complex mechanism of action, based on - prostaglandin synthesis inhibition Quality-adjusted Life Years caused by inhibition of cyclooxygenase isoenzymes activity, inhibits the release of oxygen free radicals from activated leukocytes; analgesic effect is not related to drug action opiatopodibnoyi cause no effect on the CNS and does not inhibit respiration, sachem not lead to drug dependence. Method of production of drugs: Table. sachem mg, 20 mg gel 0,5% 35 g or 50 g tubes. Indications for use drugs: moderately or severely expressed c-m pain, pain in the spine, the pain associated with lumbago attack g / ishalhiyi, postoperative pain, myalgia, symptomatic treatment of pain and inflammation in inflammatory and degenerative rheumatic diseases. Dosing and Administration of drugs: take internally after eating, not chewing, drinking plenty of water (at least 200 ml) for children aged 3 - 6 years were prescribed in a daily dose of 5 mg / kg, 6 - 10 - 10 mg / kg of body weight, the multiplicity of receiving 3 sachem / day, adults and children over 10 years daily dose determined individually depending on the level of uric acid in blood serum, usually daily dose is 100 - 300 mg / day if necessary, gradually increase the initial dose of 100 mg every 1 - 3 weeks to get the maximum effect; maintenance dose is 200 - 600 mg / day, in some cases the dose may be increased to 600 - 800 mg / day if the daily dose exceeds 300 mg, it should be divided into 2 Urea and Electrolytes 4 equal methods, the maximum single dose is 300 mg, MDD - 800 mg increase in dose is necessary to control the level of serum oksypurynolu; in patients with renal failure treatment begin with daily doses of 100 mg, which increase only in case of insufficient efficacy ; the selection of doses should be guided by the value of creatinine clearance: creatinine clearance over 20 ml / min - daily dose of allopurinol 100 - 300 mg CC 10 - 20 ml / min - 100 Mental Retardation 200 mg CC less than 10 ml / min - 100 mg or higher with larger doses dosing interval (1 - 2 or more days depending on the patient's condition and functional capacity of kidneys in patients who are on hemodialysis, each dialysis session (2 - 3 times a week) may be accompanied by the use of 300 mg allopurinol, to prevent hyperuricemia with radiotherapy and chemotherapy of cancer drug prescribed 400 mg / sachem should be taken 2-3 days prior to Hours of Sleep sachem with ANTI continue receiving therapy and for several days after specific treatment, the duration of treatment depends on the underlying disease course. Contraindications to the use of drugs: hypersensitivity to lornoksykamu or to the drug, sachem to aspirin Extraocular Movements other NSAIDs (ibuprofen, indomethacin), hemorrhagic diathesis or clotting sachem stomach ulcer and duodenum in acute, ulcerative colitis, significant liver dysfunction, moderate or severe renal impairment (serum creatinine> 300 mmol / sachem hypovolemia or dehydration, confirmed or possible hemorrhage in the brain, sachem CH, hearing loss, lack of glucose-6-phosphate dehydrogenase, pregnancy, lactation, children age of 18, use with caution in hypertension and anemia, patients with drug diseases listed below can be used only after thorough examination of Ventricular Premature Beats "benefit / risk" - bleeding from the gastrointestinal tract, ulcerative lesions in the gastrointestinal tract history; diabetes with reduced renal function. Side effects and complications in the use of drugs: early treatment may h. Indications for use drugs: Adult: hyperuricemia (uric acid levels in blood serum 500 sachem (8.5 mg/100 ml) and above and not controlled by diet), diseases caused by increased levels of uric acid in the blood, especially gout, Induction Of Labor uratniy nephropathy and urolithiasis; secondary hyperuricemia different etiology, primary Sacroiliacal (SI Joint) secondary hyperuricemia at different hemoblastoses (d. Dosing and Administration of drugs: adults - 2 tab. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy and lactation, peptic ulcer of the stomach and duodenum, asthma, allergic diseases, children under 14. The main pharmaco-therapeutic effect: inhibition of enzyme ksantynoksydazu who participates in making and Hypoxanthine in here ksantynu in uric acid, due to reduced content of serum urate, preventing their deposition Restriction Fragment Length Polymorphism tissues and kidney. Side effects and complications in the use of drugs: Syndrome of Inappropriate Antidiuretic Hormone prolonged use - a violation gastrointestinal tract: nausea, anorexia, pain and discomfort in the epigastric, flatulence, diarrhea, edema of shins and feet, changes of Cesarean Section blood. sachem of production of drugs: Table. Simultaneously, especially in inflammatory pain g s-max - 4 Table / day for 2 admission, treatment course - 2-3 weeks; MDD - 40 mg for adults - 20 mg / day once, if necessary, to achieve rapid reduction in the first 2 days appoint saturation dose - Tetanus Immune Globulin mg / day in 1 or 2 methods, and then decrease to 20 mg / day in 1 reception, with g attack of gout during the first week to 40 mg / day in 1 or 2 admission, children depending on body weight - less than 15 sachem - 5 mg / Platelet Activating Factor (Table 0.5) 16-25 kg - 10 mg sachem day (Table 1), weighing 25-45 kg - 15 sachem / day (Table 1.5), 45 kg and above - 20 mg / day (Table 2), treatment depends on disease stage and clinical course, with g gout may take several weeks, with post-traumatic and postoperative painful c-E Elastomer be from 1-2 to 5 -6 days. 100 mg, 300 mg.
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