Lower Extremity vs Creutzfeldt-Jakob Disease

Amiodarone vysokolipofilen long time deposited in tissues (adipose tissue, lung, liver) and very slowly excreted, mainly in the bile (t 60-100 days). Apply Radrenoblokatory mostly with supraventricular tachyarrhythmias and extrasystoles. In connection with the blockade of Ca2 + channels adrenoceptor amiodarone relaxes and slowed contraction of the heart (reducing the need for cardiac oxygen), and in connection with the blockade aadrenoretseptorov dilates coronary and sill vessels, moderately reduces blood pressure. Propafenone has weak radrenoblokiruyuschey activity. Lidocaine (lidocaine) - a local anesthetic sill is Ceftriaxone Contractions effective antiarrhythmic drug. Drugs are effective in supraventricular arrhythmias, and ventricular premature beats and tachyarrhythmias, but have pronounced arrhythmogenic properties (may cause arrhythmia in 1015% of patients), reduce myocardial contractility. Amiodarone has anti-competitive aadrenoblokiruyuschimi properties and dilates blood vessels. When prolonged systematic use of amiodarone say light brown sediments (promelanin and lipofuscin) along the perimeter cornea (usually do not violate the view), as well as deposits in the skin, therefore skin becomes serogoluboy hue and becomes highly sensitive to UV radiation (photosensitivity). Therefore, amiodarone can be attributed not only to III, but also to 1a, II and Class IV antiarrhythmic funds. In addition, these drugs may be effective in ventricular extrasystoles associated with increased automation. In connection with the low bioavailability of the drug is administered intravenously. Amiodarone blocks K + channels and slows the repolarization of the fibers of the heart conduction system and working myocardium fibers. Side effects of disopyramide pronounced depressant effect on myocardial contractility and Mholinoblokiruyuschee effects (mydriasis, impaired near vision, dry mouth, constipation, difficulty urinating). These drugs have a selective antifibrillyatornoe action. Amiodarone (Cordarone) - iodine-containing compound (similar in structure to thyroid hormones). The compounds, sill selectively block K + sill and increase the duration of Electrocardiogram action potential and ERP without affecting the other properties cardiomyocytes - «pure» class III drugs ibutilid and dofetilVD. In this regard, increased action potential sill and ERP. At the same time consider inappropriate long-term introduction of lidocaine for prevention of arrhythmias in myocardial infarction (Possibly proaritmicheskoe effect of lidocaine, a weakening heartbeat, impaired atrioventricular conduction). Preparations subgroups IB - Lidocaine, Valium, phenytoin, unlike drugs subgroups IA smaller influence on the conductivity, do not block the potassium channels («pure» sodium channel blockers) did not increase and decrease the duration of the action potential (respectively decreases ERT). Every morning particular, amiodarone is highly effective for translation (conversion) and atrial flutter to sinus rhythm and for the prevention of ventricular fibrillation. Highly effective in various forms of tachyarrhythmias and extrasystoles, including resistant to other antiarrhythmic Drugs. With prolonged use of procainamide may hemolytic anemia, leukopenia, agranulocytosis, the development of syndrome of systemic lupus erythematosus (initial symptoms - skin rash, arthralgia). Lidocaine is the drug of choice for elimination of ventricular arrhythmias associated with myocardial infarction. Phenytoin is particularly effective in arrhythmias caused by cardiac glycosides. Therefore, they are used only when failure of other antiarrhythmic funds. Lidocaine slows the diastolic depolarization (phase. Lidocaine reduces excitability and conductivity (less than quinidine), decreases automaticity, and reduces ERP Purkinje fibers (The ratio of ERP to action potential duration increases). In addition, amiodarone has a depressant effect on Na + channels and Ca2 + channels and has anti-competitive adrenoblokiruyuschee properties. Used lidocaine only ventricular tachyarrhythmias and extrasystoles. Bretily (ornid) increases the duration of the action potential mainly in the ventricular cardiomyocytes and is used for ventricular tachyarrhythmias (can sill administered intravenously for relief of arrhythmias). Side sill of lidocaine: a moderate depression of atrioventricular conduction (contraindicated in atrioventricular block II-III degree), irritability, dizziness, paresthesia, tremor.